Ten zipper barriers need to be replaced after damage was discovered earlier in the week.
Department of Transportation crews say to make repairs, the zipperlane will be deployed at 10:30 p.m. Wednesday near Nimitz Highway.
Officials say the Zipper Mobile will reach Kaamilo overpass area between 1 a.m. and 1:30 a.m. Thursday.
Repairs to the barriers will be made near the Kaamilo overpass in the westbound direction.
Two left lanes will be closed as drivers approach the work area.
The Pearl City Viaduct Deck repairs will also continue in the right lanes.
One-lane will be closed at the Aiea pedestrian overpass and a second lane will be closed at the Kaonohi overpass.
The State Department of Transportation advises motorists to be cautious while driving through the work zone.