Honolulu police have reopened Kalanianaole Highway between Tinker Road and Aloiloi Street after an accident.
The incident happened just after 7 a.m. Wednesday.
According to the Honolulu Emergency Medical Services, a 40-year old woman and a 21-year-old man was sent to the hospital in serious condition.
Police have closed the Highway while they investigated the accident. All roads reopened just after 8 a.m.