A portion of Farrington Highway was closed Sunday night due to a motor vehicle accident.
The closure was in the westbound direction between Tracks Beach and Black Rock Beach.
Officials say a car was heading in the Honolulu bound direction when the driver crossed the center median and slammed into a retaining wall.
One person was taken to the hospital in critical condition, three were taken in serious condition.
Traffic was contra-flowed in the eastbound direction to allow traffic to flow into Waianae.
The road was reopened around 11:00 p.m.