Emergency crews have cleared a crash involving multiple vehicles on the H-1 Freeway near Makakilo.
The initial call came in at around 2:40 p.m. in the westbound direction, and shut down three right lanes.
According to Emergency Medical Services, a 20-year-old man and an 11-year-old girl were hospitalized in serious condition.
They were in two different vehicles, officials said.
All lanes were reopened by 4:45 p.m.