The Marquee Matchup this week pits (2) Saint Louis against (3) Punahou in a showdown of unbeaten teams.
The Buffanblu beat Kamehameha last week, while the Crusaders handed Iolani its first loss of the season.
Quarterbacks Tua Tagovailoa for Saint Louis and Nicholas Kapule of Punahou figure to be the players to watch.
Punahou is undefeated in the first conference matchup of the season between the schools since 2011.
Saint Louis leads the all-time series 62-27-1.
The game kicks off Friday night at Aloha Stadium.