Tennessee rookie Marcus Mariota was 16 for 24 for 185 yards and an interception.
The Titans QB went 28-39 for 371 yards, no interceptions, and four touchdowns for a 135.7 passer rating.
The Hawaii-born quarterback threw four TD passes with no interceptions.
Mike Mularkey will take over as interim coach.
The Miami Dolphins player that caused the injury last Sunday was fined a total of $37,000 by the NFL.
The hearings will be held later this month in Oakland, St. Louis and San Diego.
The rookie quarterback needed a knee brace after being hit low.
The aggressive Buffalo defense held Marcus Mariota in check and made a key interception late in the game to seal the win.
Mariota threw for 367 yards and 2 TDs, but one costly interception was returned for a Colts touchdown.
The rookie quarterback was hit 11 times, sacked 7 times and lost two fumbles.
The Hawaii-born rookie quarterback ended the day 13-of-16, 209 yards, no INTs, and a perfect 158.3 QB rating.
Quarterbacks previously drafted No. 1 and 2 went 5-5 in their inaugural NFL starts.
All three teams are racing to claim a piece of the eager Los Angeles market.
Gifford was the NFL’s Most Valuable Player in 1956 when he led the New York Giants to a league championship.
Smith was arrested for driving under the influence, hit-and-run, and vandalism.
Marcus Mariota knows he disappointed many Oregon Ducks fans was drafted into the NFL.
So much for all that talk about how the quarterback might be too quiet.
The Cardinals say she is believed to be the first woman to hold a coaching position of any kind in the NFL.
Early Thursday morning, KHON2 was invited to Sandy Beach as the Heisman Trophy winner filmed a commercial and photo shoot.
The family posted a statement on Facebook saying he died of “complications associated with colon cancer.”